CircRNA-mediated heterogeneous ceRNA regulation mechanism in periodontitis and peri-implantitis.

ABSTRACT:

Background

Performing a comprehensive study on the differential expression of mRNAs, miRNAs, and circRNAs in the context of peri-implantitis and periodontitis has beneficial advantages to identify unique molecular signatures and pathways that may contribute to our understanding of these conditions.

Methods

Gingival tissues from healthy individuals and peri-implantitis and periodontitis patients were obtained to identify differential expression genes (DEG) by Illumina HiSeq 2500 instrument. Differential expression analysis was conducted using R statistical software, with significance set at P < 0.05 and fold greater than 2. Functional enrichment analysis of the DEGs was conducted using the Reactome, Gene ontology and KEGG databases.

Results

Significant differences in m

SUBMITTER: Zhou H 

PROVIDER: S-EPMC11657947 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature