Multiomics analyses reveal adipose-derived stem cells inhibit the inflammatory response of M1-like macrophages through secreting lactate.

ABSTRACT:

Background

Adipose-derived stem cells (ADSCs) are widely used in the field of regenerative medicine because of their various functions, including anti-inflammatory effects. ADSCs are considered to exert their anti-inflammatory effects by secreting anti-inflammatory cytokines and extracellular vesicles. Although recent studies have reported that metabolites have a variety of physiological activities, whether those secreted by ADSCs have anti-inflammatory properties remains unclear. Here, we performed multiomics analyses to examine the effect of ADSC-derived metabolites on M1-like macrophages, which play an important role in inflammatory responses.

Methods

The concentration of metabolites in the culture supernatant of ADSCs was quantified using capillary electrophoresis time-o

SUBMITTER: Horie T 

PROVIDER: S-EPMC11657992 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature