Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages.

ABSTRACT: Immunomodulation has emerged as a promising strategy for promoting bone regeneration. However, designing osteoimmunomodulatory biomaterial that can respond to mechanical stress in the unique microenvironment of alveolar bone under continuous occlusal stress remains a significant challenge. Herein, a wireless piezoelectric stimulation system, namely, piezoelectric hydrogel incorporating BaTiO₃ nanoparticles (BTO NPs), is successfully developed to generate piezoelectric potentials for modulating macrophage reprogramming. The piezoelectric stimulation reprograms macrophages towards the M2 phenotype, which subsequently induces osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). RNA sequencing analysis reveals that piezoelectricity-modulated macrophage M2 polari

SUBMITTER: Sui B 

PROVIDER: S-EPMC11657998 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature