Ultrasound nanodroplets loaded with Siglec-G siRNA and Fe₃O₄ activate macrophages and enhance phagocytosis for immunotherapy of triple-negative breast cancer.

ABSTRACT:

Background

The progression of triple-negative breast cancer is shaped by both tumor cells and the surrounding tumor microenvironment (TME). Within the TME, tumor-associated macrophages (TAMs) represent a significant cell population and have emerged as a primary target for cancer therapy. As antigen-presenting cells within the innate immune system, macrophages are pivotal in tumor immunotherapy through their phagocytic functions. Due to the highly dynamic and heterogeneous nature of TAMs, re-polarizing them to the anti-tumor M1 phenotype can amplify anti-tumor effects and help mitigate the immunosuppressive TME.

Results

In this study, we designed and constructed an ultrasound-responsive targeted nanodrug delivery system to deliver Siglec-G siRNA and Fe₃O₄

SUBMITTER: Yin C 

PROVIDER: S-EPMC11658085 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature