Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a partially heritable neurodevelopmental trait, and people with ASD may also have other co-occurring trait such as ADHD, anxiety disorders, depression, mental health issues, learning difficulty, physical health traits and communication challenges. The concomitant development of ASD and other neurological traits is assumed to result from a complex interplay between genetics and the environment. However, only a limited number of studies have performed multivariate genome-wide association studies (GWAS) for ASD.

Methods

We conducted to-date the largest multivariate GWAS on ASD and 8 ASD co-occurring traits (ADHD, ADHD childhood, anxiety stress (ASDR), bipolar (BIP), disruptive behaviour (DBD), educational attainment (EA), major depre

SUBMITTER: Salenius K 

PROVIDER: S-EPMC11658126 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature