Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes.

ABSTRACT:

Background

Beyond their conventional roles in hemostasis and wound healing, platelets have been shown to facilitate hematogenous metastasis by interacting with cancer cells. Depending on the activation route, platelets also generate different platelet-derived extracellular vesicles (PEVs) that may educate cancer cells in the circulation or within the tumor microenvironment. We engaged different platelet-activating receptors, including glycoprotein VI and C-type lectin-like receptor 2, to generate a spectrum of PEV types. This allowed us to investigate the differential capacity of PEVs to alter cancer hallmark functions such as proliferation, invasion, and pro-angiogenic potential using melanoma as a model. Additionally, we analyzed changes in the cell transcriptomes and cancer EV p

SUBMITTER: Tavukcuoglu Z 

PROVIDER: S-EPMC11658145 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature