Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients' populations.

ABSTRACT:

Background

No authoritative books or guidelines are currently available for revealing the interrelationships of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). Moreover, no consensus on this issue has been reached among previously published epidemiological studies or meta-analyses.

Purpose

We first took advantage of Mendelian randomization to clarify this issue and provide clinical implications for these patients' populations.

Methods

Bidirectional two-sample and mediator Mendelian randomization were applied to explore the causal relationships among prostatitis, BPH, and PCa. Sensitivity analyses, including phenotype scanning, heterogeneity, pleiotropy, leave-one-out analysis, and the Steiger test, were conducted to evaluate the robustness

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11658280 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature