Neutrophil extracellular traps and oxidative stress in systemic lupus erythematosus patients with and without renal involvement.

ABSTRACT:

Objectives

To investigate the levels of plasma neutrophil extracellular traps (NETs) and free thiols, the latter reflecting systemic oxidative stress (OS), and to explore the relationship between NETs and OS in quiescent systemic lupus erythematosus (SLE) patients with and without renal involvement.

Methods

Plasma levels of NETs and free thiols were measured cross-sectionally in 100 SLE patients with low disease activity (SLEDAI < 5), of whom 73 patients had no renal involvement (non-LN) and 27 patients had lupus nephritis (LN). Additionally, 22 healthy controls (HCs) were included. NETs were measured using a myeloperoxidase-DNA complex ELISA and free thiols were measured using a thiol assay kit.

Results

NETs levels were significantly higher in both non-LN and LN pati

SUBMITTER: Liu L 

PROVIDER: S-EPMC11658285 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature