GG-NER's role in androgen receptor signaling inhibitor response for advanced prostate cancer.

ABSTRACT:

Background

Advanced prostate cancer (PCa) often initially responds to androgen receptor signaling inhibitors (ARSI) but frequently develops resistance, driven by tumor heterogeneity and therapeutic pressure. Addressing the clinical challenge of identifying non-responsive patients and discovering new therapeutic targets is urgently needed.

Methods

We utilized single-sample gene set enrichment analysis (ssGSEA) to elucidate the influence of the GG-NER pathway on ARSI response in PCa. We then constructed and validated a prognostic model based on this pathway using LASSO regression, Kaplan-Meier analysis, Cox regression, and ROC analysis. Additionally, we mapped tumor mutations to delineate the mutational landscapes across different risk groups and explored functional pathways t

SUBMITTER: Zhong C 

PROVIDER: S-EPMC11658306 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature