Investigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study.

ABSTRACT:

Background

The adverse effects of environmental toxic metal exposure on human health are well-documented. However, the specific influence of heavy metal exposure on stroke prevalence remains underexplored.

Methods

This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018 to investigate the association between blood metal concentrations and the incidence of stroke. Four analytical approaches-logistic regression, Restricted Cubic Splines (RCS), Weighted Quantile Sum regression (WQS), and Bayesian Kernel Machine Regression (BKMR)-were employed to assess the relationship, with a mediation analysis conducted to explore the role of inflammatory markers in Pb exposure-induced stroke.

Results

Among the 9,399 partici

SUBMITTER: He J 

PROVIDER: S-EPMC11658309 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature