General Anesthesia Occludes Ketamine's Antidepressant Response in a Rodent Model of Chronic Stress.

ABSTRACT:

Introduction

Psychedelic-induced experiences are thought to play an important role in the therapeutic actions of rapid-acting antidepressants. General anesthesia is one scenario in which patients can be rendered unconscious and masked to the psychedelic treatment, providing a simple yet effective method to examine drug-induced changes in the brain devoid of experiences.

Methods

Chronically stressed adult C57/BL6 male mice were given subhypnotic ketamine alone or ketamine and GABAergic anesthetic isoflurane at sedative (0.6%) and general anesthetic levels (1.2%). Behavioral testing and in vivo two-photon neuronal calcium responses were recorded at the time of drug administration. Antidepressant-like responses were recorded 24 h later.

Results

We find that both k

SUBMITTER: Markman D 

PROVIDER: S-EPMC11658382 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature