Low-Dose LSD Alters Early and Late Event-Related Potentials to Emotional Faces.

ABSTRACT:

Introduction

Despite widespread popular interest in the use of low doses of Lysergic acid diethylamide (LSD) to improve mood, little is known about how these doses affect emotional processing in the brain. In this study, we tested the effect of a single low dose of LSD (26 µg) compared with placebo on electroencephalogram (EEG) event-related potentials (ERP: N170, P300 and Mismatch Negativity) in healthy adults, while participants viewed angry, happy, and neutral faces. We hypothesized that the drug might affect either neutral faces, which are sometimes perceived as threatening, or emotional faces.

Methods

Healthy young adults (n = 39) received LSD (26 µg or placebo sublingually) before completing an oddball task with emotional facial expressions during EEG recording.

SUBMITTER: Haggarty C 

PROVIDER: S-EPMC11658383 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature