Is there a role for angiotensin II-receptor blockers for ascending aorta dilatation in pediatric patients with normally functioning bicuspid aortic valve?

ABSTRACT:

Background

Currently there are no data regarding medical therapy of aortic dilatation in pediatric patients with normally functioning bicuspid aortic valve (BAV). Aim of the study was to describe the rates of change of aortic root diameters in untreated pediatric patients with normally functioning BAV and in patients with documented progressive dilatation treated with medical therapy.

Methods

Retrospective analysis performed on 191 pediatric patients with normally functioning BAV followed from 2005 to 2021 with serial examinations.

Results

Aortic root dilatation was observed in 46.3% of patients, was mainly localized at the proximal ascending aorta and judged mild. After a mean follow-up of 3.7 ± 2.7 years among 175 untreated patients 52.6% presented a new onset or pr

SUBMITTER: Mariucci E 

PROVIDER: S-EPMC11658430 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature