Evaluation of inflammation adjustment methods to assess iron deficiency using longitudinal data from norovirus human challenge trials.

ABSTRACT: Accounting for inflammation is necessary to assess iron deficiency using ferritin. A limitation of existing inflammation-adjustment methods is reliance on cross-sectional data to evaluate method performance. The study objective was to evaluate three inflammation-adjustment methods using longitudinal data from two controlled trials where apparently healthy adults (n = 52) were exposed to norovirus. Correction factors (CF), the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) regression correction (BRC), and restricted cubic splines (RCS) were used to adjust the influence of inflammation on ferritin using alpha-1-acid glycoprotein (AGP) and/or C-reactive protein (CRP). Blood was collected at baseline (day 0, pre-exposure to norovirus) and at 9 time points po

SUBMITTER: Ko YA 

PROVIDER: S-EPMC11658468 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature