Maternal cytokine profiles in second and early third trimester are not predictive of preterm birth.

ABSTRACT: Previous studies have investigated whether inflammatory cytokines in maternal circulation are associated with preterm birth. However, many have reported inconsistent results, and few have investigated cytokine trends through gestation, particularly with respect to subtypes of preterm birth. We explored levels of 15 inflammatory cytokines and growth factors in plasma and serum collected in the second (17-23 weeks, timepoint 1 (T1)) and third (28-32 weeks, timepoint 2 (T2)) trimesters with respect to subtypes of preterm birth: spontaneous preterm labour (sPTL), preterm premature rupture of membranes (PPROM), and medically indicated preterm birth (mPTB). The change in TNFα levels over time (T2/T1) significantly classified mPTB from term birth with an AUC of 0.79. While elevated sICAM-1 levels

SUBMITTER: Hornaday KK 

PROVIDER: S-EPMC11658620 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature