Discovery of Staircase Chirality through the Design of Unnatural Amino Acid Derivatives.

ABSTRACT: Chirality has garnered significant attention in the scientific community since its discovery by Louis Pasteur over a century ago. It has been showing a profound impact on chemical, biomedical, and materials sciences. Significant progress has been made in controlling molecular chirality, as evidenced by the several Nobel Prizes in chemistry awarded in this area, particularly for advancements in the asymmetric catalytic synthesis of molecules with central and axial chirality. However, the exploration of new types of chirality has been largely stagnant for more than half a century, likely due to the complexity and challenges inherent in this field. In this work, we present the discovery of a novel type of chirality-staircase chirality as inspired by the design and synthesis of unnatural amino

SUBMITTER: Rahman AU 

PROVIDER: S-EPMC11658802 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature