Evaluating gait and postural responses to subthalamic stimulation and levodopa: A prospective study using wearable technology.

ABSTRACT:

Background

The efficacy of subthalamic stimulation on axial signs of Parkinson's disease (PD) is debated in the literature. This study delves into the dynamic interplay of gait and posture, specifically probing their nuanced response to subthalamic stimulation and levodopa.

Methods

We used wearable sensor technology to examine alterations in the spatiotemporal parameters of gait and posture in individuals with PD before and 6 months after subthalamic deep brain stimulation (STN-DBS) surgery. Thirty-three subjects with PD were evaluated in two pre-operative and four post-operative conditions comprising OFF/ON medication and stimulation states. Standardized response mean (SRM) values were calculated to assess treatment responsiveness.

Results

Significant improvements in

SUBMITTER: Cani I 

PROVIDER: S-EPMC11658965 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature