The evaluation of prothrombin time and activated partial thromboplastin time among diabetic and healthy controls in Africa: systematic review and meta-analysis.

ABSTRACT:

Introduction

Diabetes Mellitus (DM) is a disorder of multiple etiologies characterized by chronic hyperglycemia resulting from defects in insulin secretion and/or insulin action. DM patients have a disturbance of hemostasis, leading to a prothrombotic state characterized by platelet hypersensitivity, coagulation factor disorders, and hypo-fibrinolysis. Therefore, the primary goal of this systematic review and meta-analysis was to determine the pooled Standard Mean Difference (SMD) of prothrombin time (PT) and activated partial thromboplastin time (APTT) of DM patients in Africa.

Methods

This systematic review and meta-analysis was conducted based on the guidelines of the PRISMA. PubMed, Google Scholar, Science Direct, Dove Press, Cochrane Online, and African journals online

SUBMITTER: Getu F 

PROVIDER: S-EPMC11658991 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature