Autoimmune Neurobeachin Cerebellar Ataxia.

ABSTRACT:

Background

There are more than 30 immunoglobulin G (IgG) autoantibody biomarkers of autoimmune cerebellar ataxia reported.

Objective

To describe a novel IgG biomarker targeting neurobeachin, a scaffolding protein integral to synapse formation and function.

Methods

Clinical and laboratory-based assessment was used for a novel diagnostic biomarker of autoimmune ataxia.

Results

A 46-year-old woman had ataxia onset followed by bilateral knee pain, attributable to rheumatoid arthritis. She was negative for standard neural antibodies. Her ataxia stabilized and tremor initially improved after corticosteroid treatment, but she progressed to wheelchair-dependence (on methotrexate and then rituximab) over 4 years, in keeping with the trajectory encountered by many with a

SUBMITTER: Basal E 

PROVIDER: S-EPMC11659054 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature