Pathological features of the differentiation landscape in esophageal squamous cell cancer and their correlations with prognosis.

ABSTRACT:

Background

For esophageal squamous cell carcinoma (ESCC), universally accepted pathological criteria for classification by differentiation degree are lacking. Tumor budding, single-cell invasion, and nuclear grade, recognized as prognostic factors in other carcinomas, have rarely been investigated for their correlation with differentiation and prognosis in ESCC. This study aims to determine if pathological findings can predict differentiation degree and prognosis in ESCC.

Patients and methods

This study reviewed tumor slides from 326 patients who underwent surgery for ESCC between 2007 and 2012. Tumors were evaluated for subtypes, tumor nest size, tumor stroma, and nuclear grade (nuclear diameter and mitosis) across different differentiation groups. Overall survival (OS) and

SUBMITTER: Deng J 

PROVIDER: S-EPMC11659131 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature