Theta phase precession supports memory formation and retrieval of naturalistic experience in humans.

ABSTRACT: Associating different aspects of experience with discrete events is critical for human memory. A potential mechanism for linking memory components is phase precession, during which neurons fire progressively earlier in time relative to theta oscillations. However, no direct link between phase precession and memory has been established. Here we recorded single-neuron activity and local field potentials in the human medial temporal lobe while participants (n = 22) encoded and retrieved memories of movie clips. Bouts of theta and phase precession occurred following cognitive boundaries during movie watching and following stimulus onsets during memory retrieval. Phase precession was dynamic, with different neurons exhibiting precession in different task periods. Phase precession strength provi

SUBMITTER: Zheng J 

PROVIDER: S-EPMC11659172 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature