Genomic and cell-specific regulation of benzylisoquinoline alkaloid biosynthesis in opium poppy.

ABSTRACT: Opium poppy is a crop of great commercial value as a source of several opium alkaloids for the pharmaceutical industries including morphine, codeine, thebaine, noscapine, and papaverine. Most enzymes involved in benzylisoquinoline alkaloid (BIA) biosynthesis in opium poppy have been functionally characterized, and opium poppy currently serves as a model system to study BIA metabolism in plants. BIA biosynthesis in opium poppy involves two biosynthetic gene clusters associated respectively with the morphine and noscapine branches. Recent reports have shown that genes in the same cluster are co-expressed, suggesting they might also be co-regulated. However, the transcriptional regulation of opium poppy BIA biosynthesis is not well studied. Opium poppy BIA biosynthesis involves three cell typ

SUBMITTER: Hong UVT 

PROVIDER: S-EPMC11659185 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature