Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information.

ABSTRACT: Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment, addressing the need for precise obstetric care in twin pregnancies.

SUBMITTER: Kong L 

PROVIDER: S-EPMC11659192 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature