Anemia-associated smaller brain volume and sex differences: a cross-sectional study of magnetic resonance imaging in brain health checkups.

ABSTRACT:

Introduction

Anemia is a risk factor for dementia development. However, few studies have examined the relationship between brain volume and anemia. This study aimed to analyze the association between anemia and brain volume using magnetic resonance imaging data from brain health checkups.

Method

Participants underwent brain health checkups between January 2015 and March 2022. Blood samples were collected to measure hemoglobin concentrations and mean corpuscular volumes. The modified Mini-Mental State Examination (MMSE) was used to evaluate cognitive function. Magnetic resonance images were analyzed using voxel-based Morphometry to evaluate the overall patterns of brain volume. After extracting the principal components (PCs) from PC analysis, we investigated their association

SUBMITTER: Omori N 

PROVIDER: S-EPMC11659214 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature