Time-dependent variation in immunoparalysis biomarkers among patients with sepsis and critical illness.

ABSTRACT:

Introduction

Immunoparalysis is a state of immune dysfunction characterized by a marked reduction in the immune system's responsiveness, often observed following severe infections, trauma, or critical illness. This study aimed to perform a longitudinal assessment of immune function over the initial two weeks following the onset of sepsis and critical illness.

Methods

We compared ex vivo-stimulated cytokine release from whole blood of critically ill patients to traditional markers of immunoparalysis, including monocyte Human Leukocyte Antigen (mHLA)-DR expression and absolute lymphocyte count (ALC). A total of 64 critically ill patients were recruited in a tertiary care academic medical setting, including 31 septic and 33 non-septic patients.

Results

While mHLA-DR expr

SUBMITTER: Samuelsen A 

PROVIDER: S-EPMC11659229 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature