Modular (universal) CAR-T platforms in vivo: a comprehensive systematic review.

ABSTRACT:

Background

Modular (universal) CAR T-platforms were developed to combat the limitations of traditional CAR-T therapy, allowing for multiple targeting of tumor-associated antigens and the ability to control CAR-T cell activity. The modular CAR-T platform consists of a universal receptor (signaling module) that recognizes an adapter molecule on the soluble module, which is responsible for antigen recognition. Multiple platforms have been developed over the last 12 years, and some of them have entered the clinical trial phase. This systematic review seeks to evaluate the different parameters of modular CAR-T platforms performance in animal models.

Methods

A systematic search of literature in the PubMed database and in Google Scholar and BASE (Bielefeld Academic Search Engine) s

SUBMITTER: Mohammad A 

PROVIDER: S-EPMC11659234 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature