Exploring the heterogeneity of osteosarcoma cell characteristics and metabolic states and their association with clinical prognosis.

ABSTRACT:

Background

Osteosarcoma is a malignant tumor originating from mesenchymal bone tissue, characterized by high malignancy and poor prognosis. Despite progress in comprehensive treatment approaches, the five-year survival rate remains largely unchanged, highlighting the need to clarify its underlying mechanisms and discover new therapeutic targets.

Methods

This study utilized RNA sequencing data from multiple public databases, encompassing osteosarcoma samples and healthy controls, along with single-cell RNA sequencing data. Various methods were utilized, such as differential expression analysis of genes, analysis of metabolic pathways, and weighted gene co-expression network analysis (WGCNA), to pinpoint crucial genes. Using this list of genes, we developed and validated a pro

SUBMITTER: Qin S 

PROVIDER: S-EPMC11659294 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature