Genome-wide DNA methylation and gene expression in human placentas derived from assisted reproductive technology.

ABSTRACT:

Background

Assisted reproductive technology (ART) has been associated with increased risks for growth disturbance, disrupted imprinting as well as cardiovascular and metabolic disorders. However, the molecular mechanisms and whether they are a result of the ART procedures or the underlying subfertility are unknown.

Methods

We performed genome-wide DNA methylation (EPIC Illumina microarrays) and gene expression (mRNA sequencing) analyses for a total of 80 ART and 77 control placentas. The separate analyses for placentas from different ART procedures and sexes were performed. To separate the effects of ART procedures and subfertility, 11 placentas from natural conception of subfertile couples and 12 from intrauterine insemination treatments were included.

Results

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SUBMITTER: Auvinen P 

PROVIDER: S-EPMC11659305 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature