Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.

ABSTRACT: Early life stress (ELS) can negatively impact health, increasing the risk of stress-related disorders, such as post-traumatic stress disorder (PTSD). Importantly, PTSD disproportionately affects women, emphasizing the critical need to explore how sex differences influence the genetic and metabolic neurobiological pathways underlying trauma-related behaviors. This study uses the limited bedding and nesting (LBN) paradigm to model ELS and investigate its sex-specific effects on fear memory formation. Employing innovative unsupervised behavioral classification, the current study reveals distinct behavioral patterns associated with fear acquisition and retrieval in male and female mice following ELS. Females exposed to LBN display heightened active fear responses, contrasting with males. Furth

SUBMITTER: Bordes J 

PROVIDER: S-EPMC11659400 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature