Diverse polysaccharide production and biofilm formation abilities of clinical Klebsiella pneumoniae.

ABSTRACT: Klebsiella pneumoniae infections have become a growing threat for human health. The lack of understanding of the relationship between antibiotic resistance, mucoviscosity, and biofilm formation impedes our abilities to effectively predict K. pneumoniae infection outcomes. The Multidrug-Resistant Organism Repository and Surveillance Network offers a unique opportunity into the genetic and phenotypic variabilities in the K. pneumoniae isolates. To this end, we compared the genetic profiles of these isolates with the phenotypic biofilm formation, percent mucoviscosity, and growth rates. There was a significant phenotype-genotype correlation with decreased biofilm formation and an insertion sequence in the transcriptional activator of the type III fimbrial system. Interestingly, the most mucoi

SUBMITTER: Beckman RL 

PROVIDER: S-EPMC11659406 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature