EZH2 elicits CD8⁺ T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells.

ABSTRACT: CD8⁺ T cell spatial distribution in the context of tumor microenvironment (TME) dictates the immunophenotypes of tumors, comprised of immune-infiltrated, immune-excluded and immune-desert, discriminating "hot" from "cold" tumors. The infiltration of cytotoxic CD8⁺ T cells is associated with favorable therapeutic response. Hitherto, the immunophenotypes of esophageal squamous cell carcinoma (ESCC) have not yet been comprehensively delineated. Herein, we comprehensively characterized the immunophenotypes of ESCC and identified a subset of ESCC, which was defined as cold tumor and characterized with CD8⁺ T cell-desert TME. However, the mechanism underlying the defect of CD8⁺ T cells in TME is still pending. Herein, we uncovered that tumor cell-intri

SUBMITTER: Zhu CY 

PROVIDER: S-EPMC11659476 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature