Decadal Evolution of KPC-related plasmids in Pseudomonas aeruginosa high-risk clone ST463 in Zhejiang, China.

ABSTRACT: Klebsiella pneumoniae carbapenemase-producing Pseudomonas aeruginosa (KPC-PA) isolates have quickly expanded in China, especially the high-risk clone ST463. We aimed to explore the evolution of KPC-related plasmids driving ST463 clone success. Whole-genome sequencing of 1258 clinical P. aeruginosa strains (2011-2020) identified 106 ST463-PA isolates, with a KPC prevalence of 90.6%. Early on (2011-2012), ST463-PA obtained the KPC-encoding type II (pT2-KPC) or type I plasmid (pT1-KPC) to overcome carbapenem stress. Between 2012 and 2017, pT1-KPC plasmid dominated due to its lower fitness costs and IS26-driven bla_KPC amplification ability. By 2017-2020, large fragment deletions in pT1-KPC formed pT1_del-KPC plasmid. It conferred even lower fitness costs, enhanced bla

SUBMITTER: Li Y 

PROVIDER: S-EPMC11659478 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature