Flexibility of intrinsic neural timescales during distinct behavioral states.

ABSTRACT: Recent neuroimaging studies demonstrate a heterogeneity of timescales prevalent in the brain's ongoing spontaneous activity, labeled intrinsic neural timescales (INT). At the same time, neural timescales also reflect stimulus- or task-related activity. The relationship of the INT during the brain's spontaneous activity with their involvement in task states including behavior remains unclear. To address this question, we combined calcium imaging data of spontaneously behaving mice and human electroencephalography (EEG) during rest and task states with computational modeling. We obtained four primary findings: (i) the distinct behavioral states can be accurately predicted from INT, (ii) INT become longer during behavioral states compared to rest, (iii) INT change from rest to task is correla

SUBMITTER: Catal Y 

PROVIDER: S-EPMC11659614 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature