Concentric Ring Trajectory Sampling With k-Space Reordering Enables Assessment of Tissue-Specific T₁ and T₂ Relaxation for ²H-Labeled Substrates in the Human Brain at 7 T.

ABSTRACT: Deuterium metabolic imaging (DMI) is an emerging Magnetic Resonance technique providing valuable insight into the dynamics of cellular glucose (Glc) metabolism of the human brain in vivo using deuterium-labeled (²H) glucose as non-invasive tracer. Reliable concentration estimation of ²H-Glc and downstream synthesized neurotransmitters glutamate + glutamine (Glx) requires accurate knowledge of relaxation times, but so far tissue-specific T₁ and T₂ relaxation times (e.g., in gray and white matter) have not been determined. Such measurements are time-consuming and particularly challenging in the presence of dynamically changing metabolite levels (e.g. ²H Glc and ²H Glx). This study aimed to assess T₁ and T₂

SUBMITTER: Bader V 

PROVIDER: S-EPMC11659634 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature