Development and validation of a lung biological equivalent dose-based multiregional radiomic model for predicting symptomatic radiation pneumonitis after SBRT in lung cancer patients.

ABSTRACT:

Background

This study aimed to develop and validate a multiregional radiomic-based composite model to predict symptomatic radiation pneumonitis (SRP) in non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT).

Materials and methods

189 patients from two institutions were allocated into training, internal validation and external testing cohorts. The associations between the SRP and clinic-dosimetric factors were analyzed using univariate and multivariate regression. Radiomics features were extracted from seven discrete and three composite regions of interest (ROIs), including anatomical, physical dosimetry, and biologically equivalent dose (BED) dimensions. Correlation filters and Lasso regularization were applied for feature select

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC11659668 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature