Heart Failure Is Closely Associated With the Expression Characteristics of Type I Interferon-Related Genes.

ABSTRACT:

Background

The association between the expression of type I interferon related genes (TIIRGs) and EFrHF is not well understood. This study aimed to investigate the correlation between the expression patterns of TIIRGs and EFrHF using bioinformatics analysis.

Materials and methods

An analysis was conducted to examine the expression and distribution of TIIRGs in cardiomyocytes. Afterwards, GSE5406 was utilized as the validation set, including 16 without heart failure, 86 with idiopathic dilated cardiomyopathy (IDCM), and 108 individuals with ischemic cardiomyopathy (ICM). We conducted a comparative analysis of the variations in TIIRGs gene expression across various forms of heart failure.

Results

There were eight genes that showed substantial changes between patients wi

SUBMITTER: Zhuo J 

PROVIDER: S-EPMC11659751 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature