An integrated transcriptomic analysis of brain aging and strategies for healthy aging.

ABSTRACT:

Background

It is been noted that the expression levels of numerous genes undergo changes as individuals age, and aging stands as a primary factor contributing to age-related diseases. Nevertheless, it remains uncertain whether there are common aging genes across organs or tissues, and whether these aging genes play a pivotal role in the development of age-related diseases.

Methods

In this study, we screened for aging genes using RNAseq data of 32 human tissues from GTEx. RNAseq datasets from GEO were used to study whether aging genes drives age-related diseases, or whether anti-aging solutions could reverse aging gene expression.

Results

Aging transcriptome alterations showed that brain aging differ significantly from the rest of the body, furthermore, brain tissues w

SUBMITTER: Liu H 

PROVIDER: S-EPMC11659761 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature