Prenatal Tobacco Exposure, Brain Subcortical Volumes, and Gray-White Matter Contrast.

ABSTRACT:

Importance

Maternal tobacco use during pregnancy (MTDP) remains a major public health challenge. However, the complete spectrum of effects of MTDP is not fully understood.

Objectives

To examine the longitudinal associations of MTDP and children's brain morphometric subcortical volume and gray-white matter contrast (GWC) development.

Design, setting, and participants

Cohort study of children aged 9 to 10 years at wave 1 (October 2016 to October 2018) and at a 2-year follow-up (wave 2; August 2018 to January 2021; aged 11-12 years) across 21 US sites in the Adolescent Brain Cognitive Development (ABCD) Study. Data were analyzed from October 2023 to October 2024.

Exposure

MTDP.

Main outcomes and measures

Morphometric brain measures of subcortical volume and

SUBMITTER: Puga TB 

PROVIDER: S-EPMC11659912 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature