Clinical and demographic factors modify the association between plasma phosphorylated tau-181 and cognition.

ABSTRACT:

Introduction

Plasma phosphorylated tau-181 (p-tau181) associations with global cognition and memory are clear, but the link between p-tau181 with other cognitive domains and subjective cognitive decline (SCD) across the clinical spectrum of Alzheimer's disease (AD) and how this association changes based on genetic and demographic factors is poorly understood.

Methods

Participants were drawn from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and included 1185 adults >55 years of age with plasma p-tau181 and neuropsychological test data. Linear regression models related plasma p-tau181 to neuropsychological composite and SCD scores with follow-up models examining plasma p-tau181 interactions with cognitive diagnosis, apolipoprotein E (APOE) ε4 carrier status, a

SUBMITTER: Bolton CJ 

PROVIDER: S-EPMC11659951 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature