SsMutPA: single-sample mutation-based pathway analysis approach for cancer precision medicine.

ABSTRACT:

Background

Single-sample pathway enrichment analysis is an effective approach for identifying cancer subtypes and pathway biomarkers, facilitating the development of precision medicine. However, the existing approaches focused on investigating the changes in gene expression levels but neglected somatic mutations, which play a crucial role in cancer development.

Findings

In this study, we proposed a novel single-sample mutation-based pathway analysis approach (ssMutPA) to infer individualized pathway activities by integrating somatic mutation data and the protein-protein interaction network. For each sample, ssMutPA first uses local and global weighted strategies to evaluate the effects of genes from mutations according to the network topology and then calculates a single-sam

SUBMITTER: He Y 

PROVIDER: S-EPMC11659979 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature