Electrochemical Profiling of vWFA2 for Systemic Inflammatory State Detection.

ABSTRACT: This research aims to develop a portable biosensor device for quickly detecting vWFA2, a biomarker for inflammatory conditions. This sensor could dramatically change detection methods and lead us to improve the sensitivity of our tests to overcome the limitations of conventional detection methods. Our label-free biomolecular assay is constructed on an Au-ZnO electrode surface and uses electrochemical impedance spectroscopy (EIS) to measure the capacitive change in impedance, revealing the binding effects of the target vWFA2, to the capture probe. Our developed biosensor platform exhibits greater sensitivity and specificity, covering a wide dynamic range of 750-24,000 pg/mL and showing a strong correlation with inflammatory conditions. This sensor exhibited a greater accuracy ranging from 8

SUBMITTER: David BE 

PROVIDER: S-EPMC11659992 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature