Enhanced Electrochemiluminescence Detection of Dopamine Using Antifouling PEDOT-Modified SPEs for Complex Biological Samples.

ABSTRACT: Detecting medically important biomarkers in complex biological samples without prior treatment or extraction poses a major challenge in biomedical analysis. Electrochemical methods, specifically electrochemiluminescence (ECL), show potential due to their high sensitivity, minimal background noise, and straightforward operation. This study investigates the ECL performance of screen-printed electrodes (SPEs) modified with the conductive polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and its derivatives for dopamine (DA) detection. PEDOT modification significantly enhances ECL intensity, improves sensitivity, and expands the linear range for DA detection. Functionalizing PEDOT with ethylene glycol (EG) further enhances stability, specificity, and resistance to interferences for DA detection

SUBMITTER: Kao TY 

PROVIDER: S-EPMC11659998 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature