Adverse drug events associated with capecitabine: a real-world pharmacovigilance study based on the FAERS database.

ABSTRACT:

Background

Capecitabine, a prodrug of 5-fluorouracil, is extensively utilized for the treatment of metastatic breast cancer, colorectal cancer, and gastric cancer. Nevertheless, there exist limitations in comprehending adverse reactions (AEs) in clinical practice. In this study, we investigated the distribution of AEs associated with capecitabine and explored potential rare adverse reactions by mining the Food and Drug Administration Adverse Event Reporting System (FAERS).

Objectives

Our research aimed to explore the spectrum of AEs associated with capecitabine, including both documented and potential events, to provide a comprehensive understanding of the drug's safety profile and guide clinical practice. At the same time, it provides a new direction for further research on

SUBMITTER: Liu R 

PROVIDER: S-EPMC11660075 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature