Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Background

A clinical challenge in esophageal squamous cell carcinoma (ESCC) remains the lack of applicable plasma biomarkers for screening and diagnosis. Circular RNAs (circRNAs) hold great potential as biomarkers for cancer. The study aims to explore a circRNA as a potential plasma biomarker for screening strategies and diagnostic approaches to ESCC.

Methods

Upregulated circRNAs were identified through RNA sequencing, with circCYP24A1 being identified as the target circRNA. Fluorescence in situ hybridization was employed to detect the expression of circCYP24A1 in ESCC tissue microarrays, aiming to assess the expression of circCYP24A1 in a large population and its correlation with clinical indicators. Subsequently, qRT-PCR analysis was performed on plasma samples from both

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11660079 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature