Optimization of physicochemical properties of theophylline by forming cocrystals with amino acids.

ABSTRACT: This study presents the synthesis and characterization of novel cocrystal structures of theophylline (THE) with the amino acids gamma-aminobutyric acid (GABA) and l-arginine (ARG). Despite a large number of reports about THE cocrystals, no crystallographic parameters of cocrystals formed by THE and amino acids have been reported. THE is characterized by low solubility, while amino acids as cocrystal co-formers (CCFs) are increasingly recognized for their high solubility and safety. Consequently, the synthesis of cocrystals with amino acids has garnered considerable research interest. To optimize THE's physicochemical properties, amino acids were chosen as CCFs, resulting in the synthesis of two novel cocrystals: THE-GABA and THE-ARG-2H₂O. Comprehensive characterization, such as

SUBMITTER: Li Q 

PROVIDER: S-EPMC11660086 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature