Exploring the Role of Thioredoxin system in Cancer Immunotherapy.

ABSTRACT: Purpose: The thioredoxin (Trx) system is integral to redox regulation and participates in several physiological processes, including tumor growth, immune response, and stem cell differentiation. We have performed a comprehensive and holistic analysis of the Trx system in tumor immunity in this study. Methods: A study using the Human Protein Atlas (HPA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC) databases was conducted to determine the expression and distribution of Trx system proteins. To explore and validate the correlation between Trx system expression levels and tumor progression, GTEx and TCGA datasets were used. Western blotting was used to measure Trx system expression in lung cancer cell lines, while MTT assays were used to measure cell proliferation. The

SUBMITTER: Sun L 

PROVIDER: S-EPMC11660121 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature