Knockdown of HOXD13 in Oral Squamous Cell Carcinoma Inhibited its Proliferation, Migration, and Influenced Fatty Acid Metabolism.

ABSTRACT: Background: HOXD13, a member of the homeobox gene family, plays a critical role in developmental processes and has been implicated in various malignancies, including pancreatic cancer and glioma. However, its role in oral squamous cell carcinoma (OSCC) remains poorly understood. This study aimed to elucidate the potential of HOXD13 as a diagnostic biomarker and therapeutic target for OSCC. Methods: We conducted a comprehensive analysis of OSCC samples from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA)-head and neck squamous cell carcinoma (HNSCC) databases. Differentially expressed genes (DEGs) with upregulated expression were identified using Venn diagrams. Functional annotation was performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and

SUBMITTER: Ma X 

PROVIDER: S-EPMC11660140 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature