Reductive alkyl-alkyl coupling from isolable nickel-alkyl complexes.

ABSTRACT: The selective cross-coupling of two alkyl electrophiles to construct complex molecules remains a challenge in organic synthesis^1,2. Known reactions are optimized for specific electrophiles and are not amenable to interchangeably varying electrophilic substrates that are sourced from common alkyl building blocks, such as amines, carboxylic acids and halides^3-5. These limitations restrict the types of alkyl substrate that can be modified and, ultimately, the chemical space that can be explored⁶. Here we report a general solution to these limitations that enables a combinatorial approach to alkyl-alkyl cross-coupling reactions. This methodology relies on the discovery of unusually persistent Ni(alkyl) complexes that can be formed directly by oxidative addition

SUBMITTER: Al Zubaydi S 

PROVIDER: S-EPMC11660167 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature