Parallelized Ultrasound-Guiding for Enhanced Light Delivery within Scattering Media.

ABSTRACT: The delivery of light over an extended area within a sample forms the basis of biomedical applications that are as relevant as photoacoustic tomography, fluorescence imaging, and phototherapy techniques. However, light scattering limits the ability of these methods to reach deep regions within biological tissues. As a result, their operational range remains confined to superficial areas of samples, posing a significant barrier to effective optical treatment and diagnosis. Here, we propose an approach to address this issue and enhance light delivery across an extended region inside scattering samples. Our strategy involves using ultrasound to directly modulate the optical properties of the sample, generating refractive index gradients that act as embedded optical waveguides. By employing tw

SUBMITTER: Mestre-Tora B 

PROVIDER: S-EPMC11660215 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature