Microbial Dysbiosis in Nasopharyngeal Carcinoma: A Pilot Study on Biomarker Potential.

ABSTRACT:

Importance

Nasopharyngeal carcinoma (NPC) is closely linked to microorganisms, especially intra-tumoral microbiota. However, the role of commensal microbiota in NPC remains underexplored, with implications for understanding disease mechanisms.

Objective

This study aims to analyze and compare the bacterial microbiota in the nasopharynx and middle meatus (MM) of individuals with NPC and those without NPC. Additionally, the study seeks to identify potential microbial biomarkers that can distinguish between NPC and non-NPC (nNPC) individuals.

Design

Cross-sectional study.

Setting

Study conducted in a clinical setting with NPC and non-NPC participants to evaluate microbial diversity relevant to NPC.

Participants

Ten NPC cases and 15 non-NPC controls were recr

SUBMITTER: Lu YT 

PROVIDER: S-EPMC11660277 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature